Overview of Heart Disease

Heart disease comes in many forms, affects individuals of all ages, and is a result of many factors, such as genetics and environment. It is also the leading cause of death in the world, accounting for more deaths than from all cancers combined.

Some sobering statistics help illustrate the burden that heart diseases impose on human health:


In the U.S., more than 30 million adults are diagnosed with heart disease.


In the U.S. approximately 35,000 children are born each year with congenital heart disease.


There are over 250 known genetically defined heart disease disorders, where the primary source of morbidity and mortality involves the heart.

Unfortunately, the rate of cardiovascular drug product approvals has declined in recent years. What’s more? Current therapies available for heart disease come with limitations – few approved products address the underlying cause of disease.

At Tenaya, we are trying to solve that problem.

We aim to deliver therapies that address the underlying causes of heart disease, to improve the lives and realities of those affected by it every day.

Tenaya Approach

Learn more about Tenaya’s potential treatment approach in this video that outlines heart conditions that affect children and adults and also provides detail into how our science is working to change future treatment outlook for patients:

Advocacy Partners

We work with patient advocacy groups to drive more awareness to heart disease and to connect to and better understand heart disease patient communities. We are proud to partner with and support patient advocacy groups doing impactful work in existing areas of unmet need.

Our Studies

TN-301 Phase 1 Clinical Trial:

Tenaya is currently enrolling healthy participants in its Phase 1 clinical study evaluating safety and tolerability of small molecule TN-301 that aims to address heart failure with preserved ejection fraction (HFpEF).

MyCLIMB Natural History Study:

Tenaya is undergoing site activation and patient enrollment in the MyCLIMB global natural history study to support and potentially expedite the future evaluation of TN-201 in pediatric patients during clinical development after earlier safety has been established in adults. For more information on our studies please contact: clinical.trials@tenayathera.com


Heart disease has many faces and touches many lives. We aim to share stories, and to add more over time, that not only detail the impact of heart disease on daily life but also shed light on the many different ways in which patients are working to drive awareness of heart disease and educate their own communities.

Read Dean's Story


To learn more about the various forms of heart disease including genetic and inherited diseases please visit: